NCC is a unique infrastructure of prospective cohort studies in the Netherlands with a focus on collection, harmonization and pooling of extensive data to address multimorbidity. Through NCC researchers will have access to a diversity of data concerning mental health, physical health, social networks, stress, life style, environment, socio-demographic and economic factors. We aim to include all population-based and population-representative Dutch cohort studies that provide advanced longitudinal clinical phenotyping and biomedical data for research into the determinants of multimorbidity. NCC brings data and researchers together to perform excellent research into unraveling the complex interplay between biological mechanisms, lifestyle, behavioral, socio-economic and environmental factors. Linkage with CBS-data, PALGA, NKR and other registries will even further strengthen the possibilities for excellent multidisciplinary research
WebsiteNetwork detailsCatalogueNEO
The Netherlands Epidemiology of Obesity
Description
Insights into how obesity leads to chronic diseases are just emerging. It has become clear that the fat cell is a potent regulator of signaling networks that affect whole body metabolism. These systemic effects include inflammation, hypercoagulability and autonomic nervous system dysfunction. The central theme of this study therefore is the toxic effect of adipose tissue. We investigate on a population level how obesity and body fat distribution affect major systemic responses leading to disease, and how these relations are influenced by individual and environmental factors. This will further our understanding of disease aetiology in individuals with and without obesity alike. A better understanding of the mechanisms underlying the development of disease in obesity will help to identify individuals who are susceptible to the detrimental metabolic, cardiovascular and other consequences of obesity and has implications for the development of prevention and treatment strategies.
General Design
- Type
- Cohort study
- Start/End data collection
- 2008 (ongoing)
Population
- Countries
- Netherlands (the)
- Number of participants
- 6671
- Population age groups
- Middle-aged (45-64 years)
- Inclusion criteria
- BMI range inclusion criterion
Organisations
Lead organisations
- Leiden University Medical Center (LUMC)Netherlands (the)https://www.lumc.nl
Networks
Part of networks
Access conditions
Researchers who wish to perform research with the NEO database can contact the scientific director of the NEO study, Renée de Mutsert.